7 Key Factors That Determine Cryopreserved Hepatocyte Quality for Drug Metabolism Studies
Cryopreserved hepatocytes are a cornerstone of in vitro drug metabolism and pharmacokinetics (DMPK) research. They retain a near-complete set of Phase I and Phase II drug-metabolizing enzymes, transporters, and cofactors, making them the most physiologically relevant model for predicting hepatic clearance, profiling metabolites, and assessing drug-drug interaction potential. But not all cryopreserved hepatocytes perform equally. […]
