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Fresh vs. Cryopreserved PBMCs: Which Delivers More Reliable Immune Assay Results?

Fresh vs. Cryopreserved PBMCs: Which Delivers More Reliable Immune Assay Results?

Peripheral blood mononuclear cells (PBMCs)sit at the heart of immunology, vaccine, and drug-development research, powering immunophenotyping, functional assays, cytokine release testing, and potency studies. One of the most common questions researchers face when designing these experiments is deceptively simple: should you use fresh PBMCs or cryopreserved PBMCs? Fresh cells have long been viewed as the […]

From Mouse to Monkey: How to Choose the Right PBMC Species for Translational Immunology

From Mouse to Monkey: How to Choose the Right PBMC Species for Translational Immunology

Peripheral blood mononuclear cells (PBMCs)are one of the most widely used primary cell types in immunology, vaccine research, and drug development. They contain the lymphocytes and monocytes that drive adaptive and innate immune responses, making them an accessible, physiologically relevant window into immune function. Yet a question that shapes the entire success of a translational […]