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  • Liu, Q., Xiong, Q., Xie, G., Chen, Q., Yang, S., Wu, Y., Zhao, L., Gao, T., Qiu, X., Jiang, J., Wang, X., Shao, J., Xie, M., & Ying, S. (2026). Self‑sufficient killing of malignant tumors by an engineered cancer‑selective gene circuit. *Cell Reports Medicine*, *7*, Article 102936. — Learn More
  • Yang, Z., Cao, S., Zhang, J., Nie, X., Wang, Z., Yang, S., Wang, J., Sun, X., Kuang, X., Huang, H., Wei, Z., Duan, P., Tang, M., Zhang, L., Ren, Z., Lan, X., Fu, Y.-X., Zhang, L., Zhang, X., & Liang, Y. (2026). Reprogramming the tumor microenvironment with antibody against membrane-proximal AXL to overcome immune checkpoint blockade resistance. Signal Transduction and Targeted Therapy, 11, Article 139. — Learn More
  • Tian, X., Liu, J., Li, Y., Wang, Y., Luo, Y., He, H., She, Y., Ma, Y., Ding, J., Zhou, P., Li, C., & Shao, F. (2025). Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. Nature. — Learn More
  • Wang, Y., Wang, Y., Yuan, W., Fan, M., Wang, X., Wang, A., Bao, Y., Zhang, Y., Tan, J. C., Wang, J., Liu, J., Huang, T., Han, Z., Pei, B., Chen, L., Ren, Z., Wang, X., Hu, L., Wu, S., … Zhao, X. (2026). Tuning the sensitivity of mechanosensory receptors through histidine scanning. Cell, 189, 1–21. — Learn More
  • Cui, M., Hu, C., Dong, J., Cheng, Y., Sun, B., Fan, C., Wang, L., & Chao, J. (2026). Multimodal DNA nanostructure barcodes for single-cell protein profiling and tumor subtyping. ACS Nano, 20, 5904–5917. — Learn More
  • Ma, Y., Wang, X., Wei, Z., Zhang, Q., Yuan, F., Xu, C., Liu, C., Wang, X., Li, L., & Jiao, Y. (2026). SLC5A11 mediates metformin-induced PD-L1 suppression to enhance cancer immunotherapy through AMPK–IRF1 signaling. Cancer Letters, 644, 218311. — Learn More
  • Wang, K., Li, X., Li, J., Yu, Z., Li, P., Xie, Y., Liu, J., Huang, H., Zhang, S., Zhang, M., Ma, W., Gao, F., Du, X., Wang, J., Capecchi, M. R., & Wu, S. (2026). Basic enables selection-free efficient knockin of large DNA in primary human T cells. Molecular Therapy, 34(4). — Learn More
  • Tian, X., Liu, J., Li, Y., Wang, Y., Luo, Y., He, H., She, Y., Ma, Y., Ding, J., Zhou, P., Li, C., & Shao, F. (2025). Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. Nature. — Learn More
  • Wang, C., Li, J., Tong, Y., Chang, H., Xu, J., Zhu, H., Yin, Y., Meng, M., & Xi, R. (2025). Anti-HER2×CCR4 bispecific antibody enhances antitumor immunity in advanced HER2-positive tumors by chemotaxis blockade and depletion of tumor-associated Tregs, without inducing systemic toxicity. Journal for ImmunoTherapy of Cancer, 13, e012829. — Learn More
  • Wang, S., Li, M., Shen, H., Zhou, W., Sun, J., Tang, Q., Liu, H., Zhang, W., Shen, Z., & Chen, W. (2025). CTLA-4 nanovesicles disrupt dendritic cell-driven CD8 T cell priming for myocardial infarction therapy. Journal of Controlled Release. — Learn More
  • Niu, X., Tang, Y., Zhang, G., Zhang, P., Dai, L., Peng, X., & Wan, X. (2025). Flagellin engineering enhances CAR-T cell function by reshaping tumor microenvironment in solid tumors. Journal for ImmunoTherapy of Cancer, 13, e010237. — Learn More
  • Cheng, Y., Li, Q., Kong, Y., Huang, A., Yang, Z., Ying, T., & Wu, Y. (2025). An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing. Journal of Leukocyte Biology, 117(8), qiaf107. — Learn More
  • Cheng, B., Li, M., Zheng, J., Liang, J., Li, Y., Liang, R., Tian, H., Zhou, Z., Ding, L., Ren, J., Shi, W., Zhou, W., Hu, H., Meng, L., Liu, K., Cai, L., Shao, X., Fang, L., & Li, H. (2025). Chemically engineered antibodies for autophagy-based receptor degradation. Nature Chemical Biology, 21(6), 855–866. — Learn More
  • Yuan, Y., Wei, Y., Jia, Z., Chu, H., Kong, D., Lei, F., Ye, F., Qian, X., Zhang, J., Zhou, X., Zhu, X., Li, Z., Liang, X., & Chen, W. (2025). Discovery of KBD4466, a selective TLR 7/8 inhibitor, for the treatment of autoimmune diseases. Journal of Medicinal Chemistry. — Learn More
  • Liu, J., Liu, W., Hu, Z., Xing, Z., Sun, G. W., Wang, M., Zhang, S. C., & Zhang, X. R. (2025). Apoferritin Nanoparticle-Based Mass Tags: A Novel Metal Tagging Strategy for Mass Cytometry. Analytical Chemistry. — Learn More
  • Lin, H. L., Ye, S. W., Zhang, S. J., Ge, T., Li, D. J., Huang, L., Zhu, L., & Mu, W. (2024). Optimizing the procedure for manufacturing clinical-grade genetically manipulated natural killer cells for adoptive immunotherapy. Cytotherapy. — Learn More
  • Lin, H., Zhang, L., Ge, T., An, N., Yang, Y., Zhang, Y., & Mu, W. (2025). Engineering CD5-targeting CAR-NK cells from peripheral blood for the treatment of CD5-positive hematological malignancies. Journal of Translational Medicine, 23(1), 409. — Learn More
  • Liu, W., Hu, Z., Jiang, W., Liu, J., Sun, G., Zhang, S., & Zhang, X. (2025). Nucleotide-based elemental mass probes for high-sensitive single-cell mass cytometry. Analytical Chemistry, 97(15), 6234–6242. — Learn More
  • Li, Z., Song, P., Liu, Y., Sun, X., Zhai, X., & Rao, Y. (2025). Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands. Journal of Medicinal Chemistry, 68(5), 3456–3468. — Learn More
  • Tang, Q., Li, M., Wang, S., Li, J., Cao, S., Liu, H., Wu, Y., Chen, Y., Shen, H., Zhang, W., Shen, Z., & Chen, W. (2024). Room-temperature-stable immunosuppressive nanovesicles for mitigating immunopathology and streamlining cardioprotection post-infarction. Chemical Engineering Journal. Advance online publication. — Learn More
  • Shen, Y., Jin, S.-J., Chen, Y.-C., Liu, W.-H., Li, Y.-M., Zhao, W.-Y., Xu, Y.-C., Chen, S.-Q., & Zhao, W.-B. (2023). Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting. Pharmacological Research, 192, 106781. — Learn More
  • Wu, S., Luo, Q., Li, F., Zhang, S., Zhang, C., Liu, J., Shao, B., Hong, Y., Tan, T., Dong, X., & Chen, B. (2024). Development of novel humanized CD19/BAFFR bicistronic chimeric antigen receptor T cells with potent antitumor activity against B-cell lineage neoplasms. British Journal of Haematology. Advance online publication. — Learn More
  • Liu, S., Miersch, S., Li, P., Bai, B., Liu, C., Qin, W., Su, J., Huang, H., Pan, J., Sidhu, S. S., & Wu, D. (2020). A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism. Journal of Molecular Biology, 432(8), 2512-2523. — Learn More
  • Cheng, J., Ge, T., Zhu, X., Wang, J., Zeng, Y., Mu, W., Cai, H., Dai, Z., Jin, J., Yang, Y., Hu, G., Mao, X., Zhou, J., Zhu, L., & Huang, L. (2023). Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia. Cancer Immunology, Immunotherapy, 72(5), 1123-1137. — Learn More
  • Cheng, J., Zhao, Y., Hu, H., Tang, L., Zeng, Y., Deng, X., Ding, S., Guo, A.-Y., Li, Q., & Zhu, X. (2023). Revealing the impact of CD70 expression on the manufacture and functions of CAR-70 T-cells based on single-cell transcriptomics. Cancer Immunology, Immunotherapy. Advance online publication. — Learn More
  • Amissah, O. B., Chen, W., Habimana, J. D., Sun, Y., Lin, L., Liu, Y., Wang, L., Liu, Z., Mukama, O., Basnet, R., Liu, H., Li, J., Ding, X., Lv, L., Chen, M., Liang, Y., Huang, R., & Li, Z. (2024). NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route. Cancer Cell International, 24(1), 64. — Learn More
  • Chen, C., Cui, H., Liu, H., Wu, Y., Ding, N., Weng, Y., Zhang, W., & Cui, Y. (2022). Role of epidermal growth factor receptor-specific CAR-T cells in the suppression of esophageal squamous cell carcinoma. Cancers, 14(24), 6021. — Learn More
  • Lei, X., Huang, A., Chen, D., Wang, X., Ji, R., Wang, J., Zhang, Y., Zhang, Y., Lu, S., Zhang, K., Chen, Q., Zhang, Y., & Yin, H. (2024). Rapid generation of long, chemically modified pegRNAs for prime editing. Nature Biotechnology. Advance online publication. — Learn More
  • Xu, Z., Wang, R., Xu, Y., Qiu, R., Chen, J., Liu, L., & Qian, Q. (2025). Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs. Scientific Reports, 15(1), 12345. — Learn More
  • Ma, Y., Zhang, Q., Xu, C., Wei, Z., Zhou, Z., Wang, X., Wang, P., Yuan, G., Liu, X., Min, S., Jiao, Y., & Yuan, F. (2026). Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis. Journal for ImmunoTherapy of Cancer, 14, e014927. — Learn More
  • Hao, M., Hou, S., Li, W., Li, K., Xue, L., Hu, Q., Zhu, L., Chen, Y., Sun, H., Ju, C., & Zhang, C. (Year). Combination of metabolic intervention and T cell therapy via cell-surface anchor-engineering augments solid tumor immunotherapy. Science Translational Medicine. Manuscript submitted for publication. — Learn More
  • Liu, X., Rong, N., Tian, Z., Rich, J., Niu, L., Li, P., Huang, L., Dong, Y., Zhou, W., Zhang, P., Chen, Y., Wang, C., Meng, L., Huang, T. J., & Zheng, H. (2024). Acoustothermal transfection for cell therapy. Science Advances, 10(8), eadk1853. — Learn More
  • Liang, F., Jin, J., Li, Q., Duan, J., Jiang, A., Chen, X., Geng, H., Wu, K., Yu, F., Zhao, X., Zhou, Y., Hu, D., & Chen, L. (2024). DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1. Cell Reports, 43(8), 114368. — Learn More
  • Zhang, Y., Huang, M., Zhang, S., Liu, T., Ye, S., Cheng, Y., Cao, Y., Chen, L., Zhu, L., Sun, X., Shen, K., Xu, Q., Li, T., Li, D., Huang, L., Mu, W., Zhao, L., & Wang, J. (2025). Improving CAR-T cell function through a targeted cytokine delivery system utilizing CAR target-modified extracellular vesicles. Experimental Hematology & Oncology, 14, Article 110. — Learn More
  • Wang, D., Lv, Y., Xie, F., Zhao, Y., Ren, B., Jin, S., Zhu, N., Qin, M., Lin, Z., Wang, L., & Wang, Y. (2026). An antioxidant, injectable hydrogel with mitochondrial fusion effect promotes inflamed dental pulp repair via immunomodulation and reactive oxygen species scavenging. Biomaterials, 329, 123985. — Learn More
  • Chen, X., Yang, M., Chen, Y., Zhang, Y., Wang, S., Meng, J., Zhu, Z., Li, W., Wei, W., Ping, Y., & Liang, T. (2026). Genetic engineering of systemically injectable oncolytic viruses for pyroptosis-accelerated cancer virotherapy. Nature Cancer, 7(1), 207–223. — Learn More
  • Zhao, K., Yan, Y., Dong, B.-T., Pan, S.-S., & Zhang, X.-Z. (2025). Senescence reprogramming unleashes tumor immune surveillance via coordinated gene modulation. Advanced Materials, e202516597. — Learn More
  • Yu Yan, Kai Zhao, Shan-Shan Pan, Yu-Liang Sun, Zhi-Yong Rao, and Xian-Zheng Zhang,Journal of the American Chemical Society, — DOI: 10.1021/jacs.5c13804
  • Cui, C., Tang, J., Chen, J., Zhang, B., Li, R., Zhang, Q., Qiu, C., Chen, R., Min, G., Sun, Z., & Weng, H. (2025). Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation. Journal of Nanobiotechnology, 23(1), 301. — Learn More